Approximately 36 healthy patients with Venezuelan ancestry have suffered severe neurologic complications, including stroke and death, after routine anesthesia. Cases are most common in South America, with 8 reported in Europe and 6 in the United States. Anesthesiologists are now advised to screen for Venezuelan maternal heritage and consider alternative anesthetic plans for at-risk individuals. Join our expert panel to learn how to prepare when caring for these patients.
Upon completion of this presentation, participants will be able to
1. Explain the genetic basis of mitochondrial-associated hypersensitivity to volatile anesthetics.
2. Describe the screening process and the role of genetic testing for identifying patients at risk for mitochondrial- associated hypersensitivity to anesthetics.
3. Formulate an anesthetic plan for a patient who screens positive for mitochondrial-associated hypersensitivity to anesthetics.
4. Discuss strategies for intraoperative monitoring and perioperative clinical decision-making of patients who screen positive for mitochondrial-associated hypersensitivity to anesthetics.
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